Understanding and recognizing the Pelger-Huët anomaly.

Microsoft Word - AHA127BF

Anomalous cells of the Pelger-Huët type appear mainly in diseases affecting granulopoiesis such as myeloproliferative disorders, aplastic anemia and agranulocytosis [1]. The association of this anomaly with disorders of the lymphatic system is rare and had been described only in 1 patient with chronic lymphocytic leukemia [2]. Recently we have encountered another patient with chronic lymphocyti...

Inherited Disorder: Pelger-Huët Anomaly

Submit Manuscript | http://medcraveonline.com Abbreviations: AML: Acute Myeloid Leukemia; CBC: Complete Blood Count; CML: Chronic Myeloid Leukemia; HIV: Human Immunodeficiency Virus; IFN-g: Interferon Gamma; INM: Inner Nuclear Membrane; LBR: Lamin B Receptor; MDS: Myelodysplastic Syndrome; NE: Nuclear Envelope; ONM: Outer Nuclear Membrane; PHA: Pelger-Huët Anomaly; PHA: PseudoPelger-Huët Anomal...

The Pelger-Huët familial anomaly of leukocytes.

Homozygous form of the Pelger-Huët anomaly.

Case of acquired or pseudo-Pelger-Huët anomaly

Pelger-Huët anomaly (PHA) is a rare benign autosomal-dominant anomaly with an incidence of ∼1 in 6000. It does not cause neutrophilia, but it can cause a false increase in band forms. It should be differentiated from acquired or pseudo-Pelger-Huët anomaly (PPHA), which has similar morphology, however; it is associated with different pathological states like Myelodysplastic syndrome, as well as ...